产品编号:E191-100

产品描述:Recombinant Human EDAR

反应种属:

实验方法:

标记:

规格:100µg

供应商:Leinco

价格(RMB):5100.00

订购:

说明书:

Recombinant Human Ectodysplasin A Receptor （EDAR）
Purified No Carrier Protein
（DL, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, FLJ94390）
Prod. No.: E191
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
Ectodysplasin A receptor （EDAR）, also known as ED1R, is a cell surface receptor of the tumor necrosis factor receptor （TNFR） family. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia （HED） （1）. It is characterized by abnormalities in the hair, teeth ａnd sweat glands. EDAR is also the genetic determinant of hair fiber thickness variation among Asian populations （2）. EDA has two splice variants, EDA-A1 ａnd EDA-A2, which differ by only two amino acids. Despite this minor difference, EDAR only binds to EDA-A1, whereas EDA-A2 binds to XEDAR. It mediates the activation of NF-κB ａnd JNK ａnd may promote caspase independent cell death （3）.

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human EDAR is Mr 44.3 kDa （monomer）. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
eysn cgeneyynqt tglcqecppc gpgeepylsc gygtkdedyg cvpcpaekfs kggyqicrrh kdcegffrat vltpgdmend aecgpclpgy ymlenrprni ygmvcyscll appntkecvg atsgasanfp gtsgsstlsp fqhahkelsg qghlatalid iegrmdpksc dkthtcppcp apellggpsv flfppkpkdt lmisrtpevt cvvvdvshed pevkfnwyvd gvevhnaktk preeqynsty rvvsvltvlh qdwlngkeyk ckvsnkalpa piektiskak gqprepqvyt lppsrdeltk nqvsltclvk gfypsdiave wesngqpenn ykttppvlds dgsfflyskl tvdksrwqqg nvfscsvmhe alhnhytqks lslspgk

Country of Origin
USA
References
1. Headon, D. J. et al. （2008） Hum. Genet. 29:1405
2. Tokunaga, K. et al. （2008） Hum. Genet. 124:179
3. Kumar, A. et al. （2001） J. Biol. Chem. 276:2668

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