产品编号:E223-10
产品描述:Recombinant Human EDA-A2
反应种属:
实验方法:
标记:
规格:10µg
供应商:Leinco
价格(RMB):4725.00
订购:
说明书:
Recombinant Human Ectodysplasin-A2 （EDA-A2）
Purified No Carrier Protein
（Tabby）
Prod. No.: E223
Source NSO Cells
Pkg. Size: 1 mg, 10 µg
Storage: -20°C to -70°C Detailed storage instructions below.
Description
Background:
Ectodysplasin A （EDA） is a ligand of the tumor necrosis factor （TNF） family that has been shown to play a crucial role in ectodermal differentiation. EDA-A1 ａnd EDA-A2 are the two main splice variants of EDA. 1 EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor （XEDAR）. EDA-A1 ａnd EDA-A2 are differentially expressed ａnd play a role in epidermal morphogenesis.
EDA-A2 is a type III integral membrane protein with three CYS region at the N terminal region. 2 EDA-A2 may be a promising agent for the gene therapy of osteosarcoma.
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human EDA-A2 is Mr 24.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 28-38 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
mhhhhhhhhh hgggsgggsg ggsiegragp pgpngppgpp gppgpqgppg ipgipgipgt tvmgppgppg ppgpqgppgl qgpsgaadka gtrenqpavv hlqgqgsaiq vkndlsggvl ndwsritmnp kvfklhprsg elevlvdgty fiysqvyyin ftdfasyevv vdekpflqct rsietgktny ntcytagvcl lkarqkiavk mvhadisinm skhttffgai rlgeapas
Country of Origin
USA
References
1. Chaudhary PM. et al.（2004）Protein Expr Purif 37:162
2. Dixit VM. et al.（2000）Science 290:523
