产品编号:C1349-1
产品描述:Recombinant Human E-Cadherin
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human E-Cadherin （E-CAD）
Purified No Carrier Protein
（Cell-CAM120/80, Uvomorulin, Arc-1, L-CAM CDH1, CD324, CDHE, UVO）
Prod. No.: C1349
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C Detailed storage instructions below.
Description
Background:
Cadherin 1, type 1, E-cadherin （epithelial）, also known as CDH1 ａnd CD32, is a tumor suppressor gene. 1, 2 The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region ａnd a highly conserved cytoplasmic tail. E-cadherin-mediated cell-cell adhesion pathway may represent a novel chemotherapeutic target for bladder cancer, prostate cancer, ａnd renal-cell carcinoma. 3
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human E-Cadherin is Mr 87.7 kDa （monomer）. However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
dwvipp iscpenekgp fpknlvqiks nkdkegkvfy sitgqgadtp pvgvfiiere tgwlkvtepl dreriatytl fshavssngn avedpmeili tvtdqndnkp eftqevfkgs vmegalpgts vmevtatdad ddvntynaai aytilsqdpe lpdknmftin rntgvisvvt tgldresfpt ytlvvqaadl qgeglsttat avitvtdtnd nppifnptty kgqvpenean vvittlkvtd adapntpawe avytilnddg gqfvvttnpv nndgilktak gldfeakqqy ilhvavtnvv pfevslttst atvtvdvldv neapifvppe krvevsedfg vgqeitsyta qepdtfmeqk ityriwrdta nwleinpdtg aistraeldr edfehvknst ytaliiatdn gspvatgtgt lllilsdvnd napipeprti ffcernpkpq viniidadlp pntspftael thgasanwti qyndptqesi ilkpkmalev gdykinlklm dnqnkdqvtt levsvcdceg aagvcrkaqp veaglqiieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgkhhhhhh
Country of Origin
USA
References
1. Christofori G et al.（1998） Am. J. Hum. Genet. 63: 1588
2. Gumbiner BM et al.（2003） J. Cell Biol.161: 1191
3. Isaacs WB et al.（1995） World J Urol.13:364
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