产品编号:D334-1

产品描述:Recombinant Human DR6

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:

说明书:

Recombinant Human Death Receptor 6 （DR6）
Purified No Carrier Protein
（TNFRSF21）
Prod. No.: D334
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
Death receptor-6 （DR6）, a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues ａnd regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4（+） T cell proliferation ａnd T helper 2 differentiation in vitro.1 DR6 contains an extracellular region ａnd an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis ａnd activates NF-κB ａnd JNK.

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Human DR6 is Mr 60.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65-75 kDa.
State of Matter
Lyophilized
Purity
>95% by SDS Page ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method

Country of Origin
USA
References
1. Na S.et al.（2006）Immunol Lett.106:42
2. Huang Y.et al.（2004）Curr. Cancer Drug Targets:97
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