产品编号:E114-25

产品描述:Recombinant Mouse CCL21

反应种属:

实验方法:

标记:

规格:25µg

供应商:Leinco

价格(RMB):4725.00

订购:

说明书:

Recombinant Mouse Chemokine （C-C Motif） Ligand 21 （CCL21）
Purified No Carrier Protein
（6Ckine, CKb9, ECL, MGC34555, SCYA21, SLC, TCA4, Exodus-2）
Prod. No.: E114
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
Chemokine （C-C motif） ligand 21 （CCL21） is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine （because it has six conserved cysteine residues instead of the four cysteines typical to chemokines）, exodus-2, ａnd secondary lymphoid-tissue chemokine （SLC）. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

In the cancer biology CCL21 seems to have multifaceted roles. CCL21 attracts CCR7 bearing cells especially T ａnd dendritic cells but also various cancer cells. Besides the antitumour role as leukocyte recruiting, CCL21 has been shown to facilitate dendritic cell functions ａnd to exert an angiostatic effect.

Human ａnd mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity.

Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse CCL21 is Mr 12 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 16-17 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile （CH3CN） ａnd 0.1% trifluoroacetic acid （TFA）.
Purity
>97% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
sdgggqdccl kysqkkipys ivrgyrkqep slgcpipail fsprkhskpe lcanpeegwv qnlmrrldqp papgkqspgc rknrgtsksg kkgkgskgck rteqtqpsrg

Country of Origin
USA
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