产品编号:B556-1

产品描述:Recombinant Human BACE-1

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:

说明书:

Recombinant Human Beta-Site APP-Cleaving Enzyme 1 （BACE-1）
Purified No Carrier Protein
（ASP2, BACE, HSPC104, FLJ90568, KIAA1149）
Prod. No.: B556
Source NSO Cells
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
BACE-1 is an aspartic protease ａnd an integral membrane protein. BACE-1 is the peptidase predominantly responsible for cleavage of the amyloid precursor protein β site in the brain to generate the amyloid β peptide. Because the amyloid β peptide is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer＇s disease. BACE-1 is expressed in a variety of human tissues. It is likely that this peptidase has functions in addition to its hydrolysis of the amyloid precursor protein. The peptidase activity of BACE-1 is optimal under mildly acidic conditions （pH 3.5 -5.5）, consistent with its proposed function in an acidic intracellular compartment.

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human BACE-1 is Mr 50 （pro） ａnd 47 （mature） kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 68-70 ａnd 65-67 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
tqhgirlpl rsglggaplg lrlpretdee peepgrrgsf vemvdnlrgk sgqgyyvemt vgsppqtlni lvdtgssnfa vgaaphpflh ryyqrqlsst yrdlrkgvyv pytqgkwege lgtdlvsiph gpnvtvrani aaitesdkff ingsnwegil glayaeiarp ddslepffds lvkqthvpnl fslqlcgagf plnqsevlas vggsmiiggi dhslytgslw ytpirrewyy eviivrvein gqdlkmdcke ynydksivds gttnlrlpkk vfeaavksik aasstekfpd gfwlgeqlvc wqagttpwni fpvislylmg evtnqsfrit ilpqqylrpv edvatsqddc ykfaisqsst gtvmgavime gfyvvfdrar krigfavsac hvhdefrtaa vegpfvtldm edcgynipqt destlmtiay hhhhhhhhhh （pro） & etdee peepgrrgsf vemvdnlrgk sgqgyyvemt vgsppqtlni lvdtgssnfa vgaaphpflh ryyqrqlsst yrdlrkgvyv pytqgkwege lgtdlvsiph gpnvtvrani aaitesdkff ingsnwegil glayaeiarp ddslepffds lvkqthvpnl fslqlcgagf plnqsevlas vggsmiiggi dhslytgslw ytpirrewyy eviivrvein gqdlkmdcke ynydksivds gttnlrlpkk vfeaavksik aasstekfpd gfwlgeqlvc wqagttpwni fpvislylmg evtnqsfrit ilpqqylrpv edvatsqddc ykfaisqsst gtvmgavime gfyvvfdrar krigfavsac hvhdefrtaa vegpfvtldm edcgynipqt destlmtiay hhhhhhhhhh （mature）

Country of Origin
USA
Related Products
Anti-Human/Mouse BACE-1 Ectodomain （Leinco Prod. No.: B596）
Anti-Human BACE-1 （Antigen Aff. Pur.） （Leinco Prod. No.: B600）