产品编号:A215-1

产品描述:Recombinant Human Apolipoprotein E2（ApoE2）

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:

说明书:

Recombinant Human Apolipoprotein E2 （ApoE2）
Prod. No.: A215
Source E. Coli
Pkg. Size: 1 mg, 500 µg

Description
Background:
Apolipoprotein E （ApoE） produced by the liver ａnd circulating macrophages, that is a constituent of every plasma lipoprotein except the smallest low density lipoproteins （LDL）. It is a key player in the recycling ａnd redistribution of lipids ａnd cholesterol. ApoE is a ligand with a high affinity for low density lipoprotein receptors （LDLR）. It regulates the activity of enzymes that metabolize lipids ａnd also makes lipids soluble. Mice ａnd humans that lack ApoE cannot remove excess lipoproteins from the plasma ａnd have an increased risk of atherosclerosis. Defective binding of ApoE to its receptors will lead to accumulation of cholesterol-rich lipoprotein particles in the plasma; this is the cause of type III hyperlipoproteinemia. There are three main isoforms of ApoE all product of alleles at a single gene locus: E2 （Cys112, Cys158）, E3 （C112, Arg158）, ａnd E4 （Arg112, Arg158）. Inheritance of ApoE2 has been associated with lower levels of total cholesterol, low-density lipoprotein cholesterol ａnd non-high-density lipoprotein cholesterol.

E2 is associated with the genetic disorder type III hyperlipoproteinemia ａnd with both increased ａnd decreased risk for atherosclerosis.

Source
E. Coli
State of Matter
Purity
>90% by SDS Page ａnd HPLC
Storage ａnd Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes ａnd store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
Data not yet available.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKCL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

Country of Origin
USA