产品编号:A345-1
产品描述:Recombinant Rat ALK-7
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Rat Activin Receptor-Like Kinase 7 （ALK-7）
Purified No Carrier Protein
Prod. No.: A345
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C Detailed storage instructions below.
Description
Background:
Activin receptor-like kinase （ALK） 7 is a type I serine/threonine kinase receptor of the transforming growth factor （TGF）-beta family of proteins.1 ALK7 is most abundantly expressed in human brain, pancreas ａnd colon.2 It negatively regulates glucose-stimulated insulin release in β-cells3 ａnd plays an important role in regulating the functional plasticity of pancreatic islets.4 ALK7 also has an important role in the regulation of body fat deposition. These has implications for the development of treatments against diabetes ａnd obesity.5
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Rat ALK-7 is Mr 35.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 47-55 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
lkcvc llcdssnftc qtegacwasv mltngkeqvi kscvslpeln aqvfchssnn vtkteccftd fcnnitlhlp taspdaprdi egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwqqgn vfscsvmhea lhnhytqksl slspgk
Country of Origin
USA
References
1. Kim SJ et al. （2004） J Biol Chem. 279: 28458
2. Ritvos O et al. （2001） Cytogenet Cell Genet. 95: 157
3. Ibanez CF et al. （2008） Proc Natl Acad Sci USA 105: 7246
4. Ibanez CF et al. （2008） PNAS 105: 7246
5. Ibanez C et al. （2008） Health & Medicine
Related Products
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Anti-Rat ALK-7-Biotin （Antigen Aff. Pur.） （Leinco Prod. No.: A400）
