产品编号:A161
产品描述:Anti-Human ASC
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human ASC
Purified No Carrier Protein
(TMS1)
Polyclonal Antibody
Prod. No.: A161
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human ASC/TMS1 recognizes Human ASC/TMS1. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1-3). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)
Known Species Cross Reactivity: Ms+
Immunogen
ASC Blocking Peptide (Leinco Prod. No.: A179)
Blocking Peptide
ASC Blocking Peptide (Leinco Prod. No.: A179)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
References
1. Masumoto, J. et al. (1999) J. Biol Chem. 274(48):33835
2. Masumoto, J. et al. (2001) Exp Cell Res. 262(2):128
3. Conway, K. E. et al. (2000)Cancer Res. 60(22):6236
4. McConnell, B. B. et al. (2000)Cancer Res. 60(22):6243 (WD0102)
Related Products
ASC Blocking Peptide (Leinco Prod. No.: A179)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
