产品编号:N156
产品描述:Anti-Human NAIP(CT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human NAIP
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: N156
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human NAIP recognizes an epitope near the C-terminus of Human NAIP. This polyclonal antibody was purified using affinity chromatography.
Background:
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy.1,2 Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO.4 suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
Known Species Cross Reactivity: Hu+
Immunogen
NAIP (CT) Blocking Peptide (Leinco Prod. No.: N169)
Blocking Peptide
NAIP (CT) Blocking Peptide (Leinco Prod. No.: N169)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human NAIP by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is PC-3 Whole Cell Lysate (Leinco Prod. No.: P166).
References
1. Roy, N. et al. (1995) Cell 80:167
2. Liston, P. et al. (2003) Oncogene 22:8568
3. Verhagen, A. M. et al. (2001) Genome Biol. 2:reviews3009.1–reviews3009.10
4. Davoodi, J. et al. (2004) J. Biol. Chem. 279:40622
Related Products
NAIP (CT) Blocking Peptide (Leinco Prod. No.: N169)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
PC-3 Whole Cell Lysate (Leinco Prod. No.: P166)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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