产品编号:N130

产品描述:Anti-Human NAK(CT)

反应种属:

实验方法:

标记:

规格:0.5mg

供应商:Leinco

价格(RMB):16095.00

订购:

说明书:

Rabbit Anti-Human NF-κB Activating Kinase (NAK)
Purified No Carrier Protein
(TBK1 )
Polyclonal Antibody

Prod. No.: N130
Host:        Rabbit
Conc.:      0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:     2-8°C

Description
Specificity:
Rabbit Anti-Human NF-κB Activating Kinase (NAK) recognizes an epitope near the C-terminus of Human and Mouse NAK. This polyclonal antibody was purified using affinity chromatography.

Background:
Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. Phosphorylation of I-κB by IκB kinase (IKK) complex leads to degradation of I-κB and activation of NF-κB. The IKK complex contains IKKα, IKKβ, and IKKγ. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κB-activating kinase), and T2K.1-3 NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κB activation in response to growth factors.2 NAK/TBK1 functions upstream of NIK and the IKK complex.1,2 NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.3

Known Species Cross Reactivity: Ms+, Hu+
Immunogen
NF-κB Activating Kinase (CT) (NAK) Blocking Peptide (Leinco Prod. No.: N151)
Blocking Peptide
NF-κB Activating Kinase (CT) (NAK) Blocking Peptide (Leinco Prod. No.: N151)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.