产品编号:P195
产品描述: Anti-Human PAK6
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):17925.00
订购:
说明书:
Rabbit Anti-Human P21-Activated Kinase 6 (PAK6)
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: P195
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human P21-Activated Kinase 6 (PAK6) recognizes Human PAK6. This polyclonal antibody was purified using affinity chromatography.
Background:
The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Known Species Cross Reactivity: Hu+
Immunogen
P21-Activated Kinase 6 Blocking Peptide (Leinco Prod. No.: P202)
Blocking Peptide
P21-Activated Kinase 6 Blocking Peptide (Leinco Prod. No.: P202)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human PAK6 by Western blot analysis at a concentration of 1.0-2.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Raji Whole Cell Lysate (Leinco Prod. No.: R1009).
References
1. Jaffer, Z. M. et al. (2002) Int. J. Biochem. Cell Biol. 34:713
2. Yang, F. et al. (2001) J. Biol. Chem. 276:15345
3. Kaur, R. et al. (2005) J. Biol. Chem. 280:3323
Related Products
P21-Activated Kinase 6 Blocking Peptide (Leinco Prod. No.: P202)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Raji Whole Cell Lysate (Leinco Prod. No.: R1009)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
