产品编号:P196
产品描述:Anti-Human Precerebellin(CT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):17925.00
订购:
说明书:
Rabbit Anti-Human Precerebellin
Purified No Carrier Protein
(Cerebellin precursor, Cbln1)
Polyclonal Antibody
Prod. No.: P196
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Precerebellin recognizes an epitope near the C-terminus of Human, Mouse and Rat Precerebellin. This polyclonal antibody was purified using affinity chromatography.
Background:
Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q.1 Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway;2 and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.3 The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus.4 Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat Precerebellin by Western blot analysis at a concentration of 2.0-4.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is 293 Whole Cell Lysate (Leinco Prod. No.: A182).
References
1. Urade, Y. et al. (1991) Proc. Natl. Acad. Sci. USA 88:1069
2. Mazzocchi, G. et al. (1999) J. Clin. Endocrinol. Metab. 84:632
3. Albertin, G. et al. (2000) Neuropeptides 34:7
4. Shamji, A. F. et al. (1985) Proc. Natl. Acad. Sci. USA 82:7145
Related Products
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
293 Whole Cell Lysate (Leinco Prod. No.: A182)
Anti-Human Precerebellin (Intermediate Domain) (Leinco Prod. No.: P197)
Precerebellin (CT) Blocking Peptide (Leinco Prod. No.: P203)
Precerebellin (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: P204)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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