产品编号:R1003
产品描述:Anti-Human RAIDD(Intermediate Domain)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human RAIDD
Purified No Carrier Protein
(CRADD)
Polyclonal Antibody
Prod. No.: R1003
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human RAIDD recognizes an epitope in the intermediate domain of Human RAIDD. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD),1 RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals.1,3 RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.
Known Species Cross Reactivity: Hu+
Immunogen
RAIDD (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: R1005)
Blocking Peptide
RAIDD (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: R1005)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human RAIDD by Western blot analysis at a dilution of 1:500-1:1000 when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive controls for Western blotting are HeLa Whole Cell Lysate (Leinco Prod. No.: H1402) and K562 Whole Cell Lysate (Leinco Prod. No.: K128).
References
1. Duan, H. et al. (1997) Nature 385:86
2. Ahmad, M. et al. (1997) Cancer Res. 57:615
3. Hofmann, K. et al. (1997) Trends Biochem. Sci. 22:155
Related Products
RAIDD (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: R1005)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
HeLa Whole Cell Lysate (Leinco Prod. No.: H1402)
K562 Whole Cell Lysate (Leinco Prod. No.: K128)
RAIDD (CT) Blocking Peptide (Leinco Prod. No.: R1004)
Anti-Human RAIDD (CT) (Leinco Prod. No.: R1002)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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