产品编号:S488
产品描述:Anti-Human STAT1α(CT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human Signal Transducer and Activator of Transcription 1 Alpha (STAT1α)
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: S488
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Signal Transducer and Activator of Transcription 1 Alpha (STAT1α) recognizes an epitope near the C-terminus of Human, Mouse and Rat STAT1α. This polyclonal antibody was purified using affinity chromatography.
Background:
STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5α, and Stat5β have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-α, IFN-β, IFN-γ and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1α and the 84 kDa STAT1β which are encoded by the same gene with splicing variant.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
Signal Transducer and Activator of Transcription 1α (CT) (STAT1α) Blocking Peptide (Leinco Prod. No.: S528)
Blocking Peptide
Signal Transducer and Activator of Transcription 1α (CT) (STAT1α) Blocking Peptide (Leinco Prod. No.: S528)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), IP, WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat STAT1α by Western blot analysis at a concentration of 1:1000-1:2000 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is HeLa Whole Cell Lysate (Leinco Prod. No.: H1402).
References
1. Leonard, W. J. et al. (1998) Annu. Rev. Immunol. 16:293
2. Schindler, C. et al. (1997) Science 277:1630
3. Schindler, C. et al. (1992) Proc. Natl. Acad. Sci. USA 89:7836
Related Products
Signal Transducer and Activator of Transcription 1α (CT) (STAT1α) Blocking Peptide (Leinco Prod. No.: S528)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
HeLa Whole Cell Lysate (Leinco Prod. No.: H1402)
Signal Transducer and Activator of Transcription 1α (CT) Blocking Peptide (Leinco Prod. No.: S535)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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