产品编号:S482
产品描述:Anti-Human SODD(NT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human SODD
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: S482
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human SODD recognizes an epitope near the N-terminus of Human, Moue and Rat SODD. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains.1 SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
SODD (NT) Blocking Peptide (Leinco Prod. No.: S491)
Blocking Peptide
SODD (NT) Blocking Peptide (Leinco Prod. No.: S491)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentraion of µg/ml.
Western Blotting: This antibody can be used to detect Human SODD by Western blot analysis at a dilution of 1:500-1:2000 when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive controls for Western blotting are HeLa Whole Cell Lysate (Leinco Prod. No.: H1402) and THP-1 Whole Cell Lysate (Leinco Prod. No.: T206).
References
1. Jiang, Y. et al. (1999) Science 283:543
Related Products
SODD (NT) Blocking Peptide (Leinco Prod. No.: S491)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
HeLa Whole Cell Lysate (Leinco Prod. No.: H1402)
THP-1 Whole Cell Lysate (Leinco Prod. No.: T206)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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