产品编号:R1242
产品描述:Anti-Human RANKL
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):17925.00
订购:
说明书:
Rabbit Anti-Human Receptor Activator of NF-κB Ligand (RANKL)
Purified No Carrier Protein
(CD254, TRANCE, hRANKL2, sOdf, TNF-Related Activation-Induced Cytokine [TRANCE], Osteoprotegrin Ligand [OPGL], Osteoclast Differentiation Factor [ODF], TNFSF11)
Polyclonal Antibody
Prod. No.: R1242
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human soluble Receptor Activator of NF-κB Ligand (sRANK Ligand) recognizes Human, Mouse and Rat sRANK Ligand. This polyclonal antibody was purified using affinity chromatography.
Background:
RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a member of the tumor necrosis factor family cytokine.1 RANKL is essential for osteoclast formation, activation, and survival.2 RANKL through interaction with its receptor RANK can modulate matrix degradation and inflammation.3 RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy. Consequently, novel drugs specifically targeting RANK, RANKL, and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various ailments associated with bone loss, such as arthritis, periodontal disease, cancer metastases, and osteoporosis.4
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
RANKL Blocking Peptide (Leinco Prod. No.: R1243)
Blocking Peptide
RANKL Blocking Peptide (Leinco Prod. No.: R1243)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
References
1. H Takayanagi et al. (2003) Arthritis Res Ther. 5: 20
2. Kostenuik PJ et al. (2005) Endocrinology 146: 3235
3. Holven KB et al. (2009) Stroke 40: 241
4. Penninger JM et al. (2008) Ann N Y Acad Sci. 1143: 123
Related Products
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Anti-Mouse RANKL (Antigen Aff. Pur.) (Leinco Prod. No.: R1144)
Recombinant Mouse RANK Ligand (Leinco Prod. No.: R1134)
Anti-Human RANKL (Leinco Prod. No.: T448)
Recombinant Mouse RANK Ligand (Leinco Prod. No.: R1255)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
