产品编号:S486
产品描述:Anti-Human Survivin(NT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):16095.00
订购:
说明书:
Rabbit Anti-Human Survivin
Purified No Carrier Protein
(TIAP)
Polyclonal Antibody
Prod. No.: S486
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Survivin recognizes an epitope near the N-terminus of Human Survivin. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP.1-3 Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
Known Species Cross Reactivity: Hu+
Immunogen
Survivin (NT) Blocking Peptide (Leinco Prod. No.: S493)
Blocking Peptide
Survivin (NT) Blocking Peptide (Leinco Prod. No.: S493)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human Survivin by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is MOLT 4 Whole Cell Lysate (Leinco Prod. No.: M1012).
References
1. Ambrosini, G. et al. (1997) Nat. Med. 3:917
2. Li, F. et al. (1998) Nature 396:580
3. Kobayashi, K. et al. (1999) Proc. Natl. Acad. Sci. USA 96:1457
Related Products
Survivin (NT) Blocking Peptide (Leinco Prod. No.: S493)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
MOLT 4 Whole Cell Lysate (Leinco Prod. No.: M1012)
Survivin (CT) (Human) Blocking Peptide (Leinco Prod. No.: S492)
Survivin (CT) (Mouse) Blocking Peptide (Leinco Prod. No.: S494)
Anti-Mouse Survivin (CT) (Leinco Prod. No.: S503)
Anti-Human Survivin (CT) (Leinco Prod. No.: S485)
Anti-Human Survivin (Antigen Aff. Pur.) (Leinco Prod. No.: S584)
Anti-Human Survivin-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: S591)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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