产品编号:T275
产品描述:Anti-Human T-cad(NT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):17925.00
订购:
说明书:
Rabbit Anti-Human T-Cadherin (T-cad)
Purified No Carrier Protein
(Cadherin-13 Precursor, Heart-Cadherin)
Polyclonal Antibody
Prod. No.: T275
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human T-Cadherin (T-cad) recognizes an epitope near the N-terminus of Human, Mouse and Rat T-cad. This polyclonal antibody was purified using affinity chromatography.
Background:
T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth.1 T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage.2 T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers.3,4 Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
T-Cadherin (NT) Blocking Peptide (Leinco Prod. No.: T296)
Blocking Peptide
T-Cadherin (NT) Blocking Peptide (Leinco Prod. No.: T296)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat T-cad by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is 3T3 Balb Whole Cell Lysate (Leinco Prod. No.: A183).
References
1. Ranscht, B. et al. (1991) Neuron 7:391
2. Ivanov, D. B. et al. (2001) Biochemistry (Moscow) 66:1175
3. Takeuchi, T. et al. (1999) Histopathology 35:87
4. Sato, M. et al. (1998) Hum. Gen. 103:96
Related Products
T-Cadherin (NT) Blocking Peptide (Leinco Prod. No.: T296)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
3T3 Balb Whole Cell Lysate (Leinco Prod. No.: A183)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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