产品编号:T278
产品描述:Anti-Human TANK(NT)
反应种属:
实验方法:
标记:
规格:0.5mg
供应商:Leinco
价格(RMB):17925.00
订购:
说明书:
Rabbit Anti-Human TANK
Purified No Carrier Protein
(TRAF Family Member-Associated NF-kappaB Activator, I-TRAF)
Polyclonal Antibody
Prod. No.: T278
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human TANK recognizes an epitope near the N-terminus of Human TANK. This polyclonal antibody was purified using affinity chromatography.
Background:
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κB proteins. At least two isoforms of TANK are known to exist.
Known Species Cross Reactivity: Hu+
Immunogen
TANK (NT) Blocking Peptide (Leinco Prod. No.: T300)
Blocking Peptide
TANK (NT) Blocking Peptide (Leinco Prod. No.: T300)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat TANK by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Daudi Whole Cell Lysate (Leinco Prod. No.: D310).
References
1. Cheng, G. et al. (1996) Genes Dev. 10:963
2. Rothe, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93:8241
3. Pomerantz, J. L. et al. (1999) EMBO J. 18:6694
4. Chariot, A. et al. (2002) J. Biol. Chem. 277:37029
Related Products
TANK (NT) Blocking Peptide (Leinco Prod. No.: T300)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Daudi Whole Cell Lysate (Leinco Prod. No.: D310)
Anti-Human TANK (CT) (Leinco Prod. No.: T277)
TANK (CT) Blocking Peptide (Leinco Prod. No.: T299)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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