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Anti-Human TRAF2(NT)

产品编号:T283

产品描述:Anti-Human TRAF2(NT)

反应种属:

实验方法:

标记:

规格:0.5mg

供应商:Leinco

价格(RMB):17925.00

订购:订购

说明书:

Rabbit Anti-Human TNF Receptor-Associated Factor 2 (TRAF2)
Purified No Carrier Protein
Polyclonal Antibody

Prod. No.: T283
Host:         Rabbit
Conc.:      0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:      2-8°C

Description
Specificity:
Rabbit Anti-Human TNF Receptor-Associated Factor 2 (TRAF2) recognizes an epitope near the N-terminus of Human, Mouse and Rat TRAF2. This polyclonal antibody was purified using affinity chromatography.

Background:

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress.1 TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity,2 and are critical for NF-κB activation in mouse B lymphocytes.3 TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells.4 TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

Known Species Cross Reactivity: Ms+, Hu+, Rt+

Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
Western Blotting: This antibody can be used to detect Human, Mouse and Rat TRAF2 by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Human Liver Tissue Lysate (Leinco Prod. No.: H1408).

 

References
1. van Kooten, C. et al. (2000) J. Leukoc. Biol. 67:2
2. Grech, A. P. et al. (2004) Immunity 21:629
3. Davies, C. C. et al. (2005) Mol. Cell. Biol. 25:980
4. Kuai, J. et al. (2003) J. Biol. Chem. 278:14363
Related Products
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Human Liver Tissue Lysate (Leinco Prod. No.: H1408)
Anti-Human TNF Receptor-Associated Factor 2 (CT) (TRAF2) (Leinco Prod. No.: T282)
TNF Receptor-Associated Factor 2 (CT) Blocking Peptide (Leinco Prod. No.: T312)
TNF Receptor-Associated Factor 2 (NT) Blocking Peptide (Leinco Prod. No.: T313)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.