产品编号:I-358

产品描述:Anti-Human IL-22R(NT)

反应种属:

实验方法:

标记:

规格:0.5mg

供应商:Leinco

价格(RMB):16095.00

订购:

说明书:

Rabbit Anti-Human Interleukin-22 Receptor (IL-22R)
Purified No Carrier Protein
(CRF2-9, IL-TIF-R1)
Polyclonal Antibody

Prod. No.: I-358
Host:          Rabbit
Conc.:     0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:         2-8°C

Description
Specificity:
Rabbit Anti-Human Interleukin-22 Receptor (IL-22R) recognizes an epitope near the N-terminus of Human and Rat IL-22R. This polyclonal antibody was purified using affinity chromatography.

Background:
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified.1-3 The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.3,4 IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Known Species Cross Reactivity: Hu+, Rt+
Immunogen
IL-22R (NT) Blocking Peptide (Leinco Prod. No.: I-359)
Blocking Peptide
IL-22R (NT) Blocking Peptide (Leinco Prod. No.: I-359)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human and Rat IL-22R by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is HepG2 Whole Cell Lysate (Leinco Prod. No.: H1404).

References
1. Dumoutier, L. et al. (2000) J. Immunol. 164(4):1814
2. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97(18):10144
3. Xie, M. H. et al. (2000) J. Biol. Chem. 275(40):31335
4. Kotenko, S. V. et al. (2001) J. Biol. Chem. 276(4):2725
Related Products
IL-22R (NT) Blocking Peptide (Leinco Prod. No.: I-359)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
HepG2 Whole Cell Lysate (Leinco Prod. No.: H1404)
IL-22R (CT) Blocking Peptide (Leinco Prod. No.: I-361)
Anti-Human IL-22R (CT) (Leinco Prod. No.: I-360)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.