产品编号:RCP9301
产品描述:Mitochondrial Glycerol-3-Phosphate Dehydrogenase
反应种属:
实验方法:
标记:
规格:10µg
供应商:Randox
价格(RMB):1995.00
订购:
说明书:
| Description: | Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus. RANDOX recombinant mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use. |
| Form: | Liquid |
| Purity: | >95% by SDS-PAGE |
| References: | Brown, L.J. et al., Gene 1996 172 (2) : 309-12. Ferrer J. et al., Diabetes 1996 45 (2) : 262-6. |
