产品编号:CYT-256-25ug

产品描述:Recombinant Human Resistin, His Tag(Resistin His)

反应种属:

实验方法:

标记:

规格:25µg

供应商:Prospec

价格(RMB):1820.00

订购:

说明书:

Resistin Human, His
Resistin Human Recombinant, His Tag
Catalog No. CYT-256

Synonyms:
Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609.

Introduction:
Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue- Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.
Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs.
Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.

Description:
9.9 kDa protein containing 93 amino acid residues fused with 4kDa His Tag fusion protein.

Source:
Escherichia Coli.

Specificity:
The amino acid sequence of the Resistin Human Recombinant is 100% homologous to the amino acid sequence of the Resistin Human without signal sequence.

Physical Appearence:
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity:
Greater than 90% as determined by SDS-PAGE.

Formulation:
Sterile filtered lyophilized powder containing no additives.

Solubility:
Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.

Stability:
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.

Applications:
Western blotting, ELISA

Usage:
Prospec's products are furnished forLABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.