产品编号:C1122

产品描述:Anti-Human CXCR4(EL)

反应种属:mouse, human

实验方法:WB

标记:

规格:0.5mg

供应商:leinco

价格(RMB):16095.00

订购:

说明书:

Rabbit Anti-Human CXCR4
Purified No Carrier Protein
(Fusin, LESTR, HUMSTR)
Polyclonal Antibody
Prod. No.: C1122
Host:      Rabbit
Conc.:     0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:   2-8°C

Description
Specificity:
Rabbit Anti-Human CXCR4 recognizes an epitope in the extracellular loop of Human CXCR4. This polyclonal antibody was purified using affinity chromatography.

Background:
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.

Known Species Cross Reactivity: Ms+, Hu+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
Western Blotting: This antibody can be used for Western blot at a 1:500 to 1:1000 dilution.

References
1. Dimitrov, D. S. (1997) Cell 91:721
2. Feng, Y. et al. (1996) Science 272:872
3. Berson, J. F. et al. (1996) J. Virol. 70:6288
4. Doranz, B. J. et al. (1996) Cell 85:1149
Related Products
CXCR4 (Extracellular Loop) Blocking Peptide (Leinco Prod. No.: C1139)
CXCR4 (NT) Blocking Peptide (Leinco Prod. No.: C1140)
Anti-Human CXCR4 (NT) (Leinco Prod. No.: C1123)
Anti-Human CXCR4-Biotin (Leinco Prod. No.: C1547)
Anti-Human CXCR4-Fluorescein (FITC) (Leinco Prod. No.: C1548)
Anti-Human CXCR4-R-phycoerythrin (R-PE) (Leinco Prod. No.: C1549)
Anti-Human CXCR4-Biotin (Leinco Prod. No.: C1550)
Anti-Human CXCR4-Biotin (Leinco Prod. No.: C1551)
Anti-Human CXCR4-R-phycoerythrin (R-PE) (Leinco Prod. No.: C1552)
Anti-Human CXCR4-Biotin (Leinco Prod. No.: C1553)
Antigen Affinity Purified Polyclonal Antibodies To Growth Factors & Cytokines

Products are for research use only. Not for use in diagnostic or therapeutic procedures