产品编号:C1120
产品描述:Anti-Human CX3CR1(EL)
反应种属:human
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human CX3CR1
Purified No Carrier Protein
(V28, CMKBRL1)
Polyclonal Antibody
Prod. No.: C1120
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human CX3CR1 recognizes an epitope in the extracellular loop of Human CX3CR1. This polyclonal antibody was purified using affinity chromatography.
Background:
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively.1-4 The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.2
Known Species Cross Reactivity: Hu+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human CX3CR1 by Western blot analysis at a dilution of 1:500 when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive controls for Western blotting are THP-1 Whole Cell Lysate (Leinco Prod. No.: T206) and 3T3 Balb Whole Cell Lysate (Leinco Prod. No.: A183).
References
1. Raport, C. J. et al. (1995) Gene 163:295
2. Combadiere, C. et al. (1995) DNA Cell Biol. 14:673
3. Combadiere. C. et al. (1998) Biochem. Biophys. Res. Commun. 253:728
4. Harrison, J. K. et al. (1994) Neurosci. Lett. 169:85
Related Products
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
THP-1 Whole Cell Lysate (Leinco Prod. No.: T206)
3T3 Balb Whole Cell Lysate (Leinco Prod. No.: A183)
Anti-Human CX3CR1 (NT) (Leinco Prod. No.: C1121)
Antigen Affinity Purified Polyclonal Antibodies To Growth Factors & Cytokines
Products are for research use only. Not for use in diagnostic or therapeutic procedures
