产品编号:A313
产品描述:Anti-Human ACE2(CT)
反应种属:human
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2)
Purified No Carrier Protein
(ACEH)
Polyclonal Antibody
Prod. No.: A313
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2) recognizes an epitope near the C-terminus of Human ACE2. This polyclonal antibody was purified using affinity chromatography.
Background:
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].1 ,or the conversion of angiotensin II to angiotensin 1-7.2 ACE 2 has direct effects on cardiac function2, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.3 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).4 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).5 Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo.
Known Species Cross Reactivity: Hu+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Acton S et al. (2000) Circ Res. 87: E1
2. Gamliel-Lazarovich A et al. (2007) Cardiovasc Res. 73: 463
3. Nabel EG et al. (2000) N Engl J Med. 347: 1795
4. Raizada MK et al. (2009) Am J Respir Crit Care Med.
5. Yuan Y et al. (2009) Tohoku J Exp Med. 217: 123
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
