产品编号:H1461

产品描述:Anti-Avian H5N1 NS1

反应种属:Virus

实验方法:ELISA

标记:

规格:0.1mg

供应商:leinco

价格(RMB):5700.00

订购:

说明书:

Rabbit Anti-Avian H5N1 NS1 (H5N1 NS1)
Purified No Carrier Protein
(Nonstructural Protein 1)
Polyclonal Antibody
Prod. No.: H1461
Host:      Rabbit
Conc.:     0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:   2-8°C

Description
Specificity:
Rabbit Anti-H5N1 NS1 recognizes H5N1 NS1. This polyclonal antibody was purified using affinity chromatography.

Background:
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called “avian flu” or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2’-5’ OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.

Known Species Cross Reactivity: Virus
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
Indirect ELISA

References
1. Thompson, W. W. et al. (2003) JAMA 289:179
2. Alexander, D. J. (2000) Vet. Microbiol. 74:3
3. Krug, R. M. et al. (2003) Virology 309:181
4. Min, J. Y. et al. (2006) Proc. Natl. Acad. Sci. USA 103:7100
Related Products
H5N1 NS1 Blocking Peptide (Leinco Prod. No.: H1465)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.