产品编号:A286
产品描述:Anti-Anthrax Protective Antigen(Anthrax PA)
反应种属:bacteria
实验方法:ELISA
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Anthrax Anthrax Protective Antigen (Anthrax PA)
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: A286
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Anthrax Protective Antigen (Anthrax PA) recognizes an epitope in the intermediate domain of Anthrax PA. This polyclonal antibody was purified using affinity chromatography.
Background:
Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
Known Species Cross Reactivity: Bacteria
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
Indirect ELISA
References
1. Schwartz, M. N. (2001) New Engl. J. Med. 345:1621
2. Moayeri, M. et al. (2004) Curr. Opin. Microbiol. 7:19
3. Bradley, K. A. et al. (2001) Nature 414:225
4. Scobie, H. M. et al. (2003) Proc. Natl. Acad. Sci. USA 100:5170
Related Products
Anti-Anthrax Protective Antigen (CT) (Leinco Prod. No.: A285)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
