产品编号:G578
产品描述:Anti-Mouse GFRα-3
反应种属:mouse, human, rat
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Mouse Glial Cell Line-Derived Neurotropic Factor Receptor Alpha 3 (GFRα-3)
Purified No Carrier Protein
(GDNFRγ, GDNFRgamma)
Polyclonal Antibody
Prod. No.: G578
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Mouse GFRα-3 recognizes a epitope in the intermediate domain human, mouse and rat GFRα-3. This polyclonal antibody was purified using affinity chromatography.
Background:
GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion.
GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.1glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ (2). Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified very recently from human and mouse and designated GFRα-3 (3-7). GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
Purified Recombinant Mouse GFRα-3 (>98%)
Blocking Peptide
GFRa-3 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: G580)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Sanicola M. et al. (2001)Eur J Neurosci 13: 2177
Related Products
GFRa-3 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: G580)
Recombinant Human GFRα-3 (Leinco Prod. No.: G650)
Anti-Human GFRα-3 (Leinco Prod. No.: G677)
Anti-Human GFR α-3 (Antigen Aff. Pur.) (Leinco Prod. No.: G684)
Anti-Human GFRα-3-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: G694)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
