产品编号:I-354
产品描述:Anti-Human IL-21R
反应种属:mouse, human, rat
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human Interleukin-21 Receptor (IL-21R)
Purified No Carrier Protein
(NILR, MGC10967)
Polyclonal Antibody
Prod. No.: I-354
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Interleukin-21 Receptor (IL-21R) recognizes an epitope in the extracellular domain of Human, Mouse and Rat IL-21R. This polyclonal antibody was purified using affinity chromatography.
Background:
Interleukin 21 receptor (IL-21R) is a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL4RA).1 IL-21R is an important amplifier of alternative macrophage activation. Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases.2 IL-21/IL-21R system may represent a new target for the treatment of Adult T-cell leukaemia (ATL).3
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
IL-21R (Extracellular Domain) Blocking Peptide (Leinco Prod. No.: I-355)
Blocking Peptide
IL-21R (Extracellular Domain) Blocking Peptide (Leinco Prod. No.: I-355)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Hackstein H et al. (2003) Genes Immun. 4: 228
2. Wynn TA et al. (2006) J Clin Invest. 116: 2044
3. Uchiyama T et al. (2005) Br J Haematol. 128: 169
Related Products
IL-21R (Extracellular Domain) Blocking Peptide (Leinco Prod. No.: I-355)
Anti-Human IL-21R (NT) (Leinco Prod. No.: I-356)
Recombinant Mouse IL-21 R (Leinco Prod. No.: I-572)
Recombinant Human IL-21 R (Leinco Prod. No.: I-599)
Anti-Human IL-21 R-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: I-609)
Anti-Human IL-21 R Subunit (Antigen Aff. Pur.) (Leinco Prod. No.: I-616)
IL-21R (NT) Blocking Peptide (Leinco Prod. No.: I-357)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
