产品编号:I-352
产品描述:Anti-Human IL-21
反应种属:human
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human Interleukin-21 (IL-21)
Purified No Carrier Protein
(Za11)
Polyclonal Antibody
Prod. No.: I-352
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Interleukin-21 (IL-21) recognizes an epitope in the intermediate domain of Human IL-21. This polyclonal antibody was purified using affinity chromatography.
Background:
Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.1,2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-153 and is a key factor in the transition between innate and adaptive immune responses.4 The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.5
Known Species Cross Reactivity: Hu+
Immunogen
IL-21 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: I-353)
Blocking Peptide
IL-21 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: I-353)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Foster D et al. (2000) Nature 408: 57
2. Clegg CH et al. (2002) J. Leukoc. Biol. 72: 856
3. Leonard WJ.et al. (2002) Science 298: 1630
4. Joannopoulos K.et al. (2003) J. Immunol. 171: 608
5. Lipsky PE. et al. (2008) Ann Rheum. Dis. 3: 83
Related Products
IL-21 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: I-353)
Anti-Mouse IL-21 (Antigen Aff. Pur.) (Leinco Prod. No.: I-728)
Anti-Mouse IL-21-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: I-787)
Recombinant Mouse IL-21 (Leinco Prod. No.: I-453)
Recombinant Human IL-21 (Leinco Prod. No.: I-452)
Human IL-21 ELISA Development Kit (Leinco Prod. No.: I-832)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
