产品编号:S503
产品描述:Anti-Mouse Survivin(CT)
反应种属:mouse
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Mouse Survivin
Purified No Carrier Protein
(TIAP, API4)
Polyclonal Antibody
Prod. No.: S503
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Mouse Survivin recognizes an epitope near the C-terminus of Mouse Survivin. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP.1-3 Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.1,3
Known Species Cross Reactivity: Ms+
Immunogen
Survivin (CT) (Mouse) Blocking Peptide (Leinco Prod. No.: S494)
Blocking Peptide
Survivin (CT) (Mouse) Blocking Peptide (Leinco Prod. No.: S494)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Mouse Survivin by Western blot analysis at a concentration of 1.0-2.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Mouse Spleen Tissue Lysate (Leinco Prod. No.: M1018).
References
1. Ambrosini, G. et al. (1997) Nat. Med. 3:917
2. Li, F. et al. (1998) Nature 396:580
3. Kobayashi, K. et al. (1999) Proc. Natl. Acad. Sci. USA 96:1457
Related Products
Survivin (CT) (Mouse) Blocking Peptide (Leinco Prod. No.: S494)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Mouse Spleen Tissue Lysate (Leinco Prod. No.: M1018)
Survivin (CT) (Human) Blocking Peptide (Leinco Prod. No.: S492)
Survivin (NT) Blocking Peptide (Leinco Prod. No.: S493)
Anti-Human Survivin (CT) (Leinco Prod. No.: S485)
Anti-Human Survivin (NT) (Leinco Prod. No.: S486)
Anti-Human Survivin (Antigen Aff. Pur.) (Leinco Prod. No.: S584)
Anti-Human Survivin-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: S591)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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