产品编号:S557
产品描述:Anti-Mouse ST2(NT)
反应种属:mouse
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Mouse ST2
Purified No Carrier Protein
(Interleukin-1 receptor-like 1)
Polyclonal Antibody
Prod. No.: S557
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1.0 mg, 0.1 mg, 0.5 mg
Storage: 2-8°
Description
Specificity:
Rabbit Anti-Mouse ST2 recognizes an epitope near the N-terminus of Mouse ST2. This polyclonal antibody was purified using affinity chromatography.
Background:
ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF (3). More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance (4,5). It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP (6).
Known Species Cross Reactivity: Ms+
Immunogen
ST2 (NT) Blocking Peptide (Leinco Prod. No.: S560)
Blocking Peptide
ST2 (NT) Blocking Peptide (Leinco Prod. No.: S560)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
2. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
3. Lanahan A, Williams JB, Sanders LK, et al. Growth factor-induced delayed early response genes. Mol Cell Biol. 1992; 12:3919-29.
4. Sweet MJ, Leung BP, Kang D, et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J. Immunol. 2001; 166:6633-9.
Related Products
ST2 (NT) Blocking Peptide (Leinco Prod. No.: S560)
Anti-Human ST2/IL-1 R4 (Leinco Prod. No.: S582)
Anti-Human ST2/IL-1 R4 (Antigen Aff. Pur.) (Leinco Prod. No.: S583)
Anti-Human ST2/IL-1 R4-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: S590)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
