产品编号:T203

产品描述:Anti-Human TACE(CT)

反应种属:mouse, human, rat

实验方法:IHC, WB

标记:

规格:0.1mg

供应商:leinco

价格(RMB):5370.00

订购:

说明书:

Rabbit Anti-Human Tumor Necrosis Factor-α Converting Enzyme (TACE)
Purified No Carrier Protein
(ADAM17, CD156b, MGC71942, cSVP)
Polyclonal Antibody

Prod. No.: T203
Host:         Rabbit
Conc.:      0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:      2-8°C

Description
Specificity:
Rabbit Anti-Human TNF-α Converting Enzyme (TACE) recognizes an epitope near the C-terminus of Human, Mouse and Rat TACE. This polyclonal antibody was purified using affinity chromatography.

Background:
TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.1 TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.2 TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)3 and a principal target for the treatment of TNF-dependent pathologies.4

Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
TACE (CT) Blocking Peptide (Leinco Prod. No.: T204)
Blocking Peptide
TACE (CT) Blocking Peptide (Leinco Prod. No.: T204)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB

References
1. Masson D et al. (2009) Int J Mol Med. 23: 41
2. B Chodynicka et al. (2008) J European Acad Dermatol & Venereol. 22: 712
3. Coffey RJ et al. (2008) Clin Cancer Res. 14: 1182
4. Blobel CP et al. (2007) J Immunol. 179: 2689
Related Products
TACE (CT) Blocking Peptide (Leinco Prod. No.: T204)
Anti-Human TACE Ectodomain (Leinco Prod. No.: T460)
Anti-Human TACE Ectodomain (Leinco Prod. No.: T461)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.