产品编号:D257
产品描述:Anti-Human DRAK1(NT)
反应种属:human
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):4635.00
订购:
说明书:
Rabbit Anti-Human DRAK1
Purified No Carrier Protein
(DAPK Related Apoptosis-inducing Kinase)
Polyclonal Antibody
Prod. No.: D257
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human DRAK1 recognizes an epitope near the N-terminus of Human DRAK1. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases.1 DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.1
Known Species Cross Reactivity: Hu+
Immunogen
DRAK1 (NT) Blocking Peptide (Leinco Prod. No.: D281)
Blocking Peptide
DRAK1 (NT) Blocking Peptide (Leinco Prod. No.: D281)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect Human DRAK1 by Western blot analysis at a concentration of 1:500-1:1,000 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive controls for Western blotting are MOLT 4 Whole Cell Lysate (Leinco Prod. No.: M1012) or A431 Whole Cell Lysate (Human Epidermoid Carcinoma) (Leinco Prod. No.: A180).
References
1. Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71
Related Products
DRAK1 (NT) Blocking Peptide (Leinco Prod. No.: D281)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
MOLT 4 Whole Cell Lysate (Leinco Prod. No.: M1012)
A431 Whole Cell Lysate (Human Epidermoid Carcinoma) (Leinco Prod. No.: A180)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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