产品编号:D254
产品描述:Anti-Human DR6(NT)
反应种属:human
实验方法:WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human Death Receptor 6 (DR6)
Purified No Carrier Protein
(TNFRSF21)
Polyclonal Antibody
Prod. No.: D254
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human DR6 recognizes an epitope near the N-terminus of Human DR6. This polyclonal antibody was purified using affinity chromatography.
Background:
Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro.1 DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK.
Known Species Cross Reactivity: Hu+
Immunogen
Purified Recombinant Human DR6 (>98%)
Blocking Peptide
DR6 (NT) Blocking Peptide (Leinco Prod. No.: D280)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
References
Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6
Related Products
DR6 (NT) Blocking Peptide (Leinco Prod. No.: D280)
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Anti-Human DR6 (Leinco Prod. No.: D348)
Anti-Human DR6-Biotin ( Antigen Aff. Pur. ) (Leinco Prod. No.: D363)
Anti-human DR6 ( Antigen Aff. Pur. ) (Leinco Prod. No.: D375)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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