产品编号:D252
产品描述:Anti-Human DR3(CT)
反应种属:mouse, human, rat
实验方法:WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human DR3
Purified No Carrier Protein
(Wsl-1, Apo-3, TRAMP, LARD)
Polyclonal Antibody
Prod. No.: D252
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human DR3 recognizes an epitope near the C-terminus of mouse, rat and human DR3. This polyclonal antibody was purified using affinity chromatography.
Background:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
DR3 (CT) Blocking Peptide (Leinco Prod. No.: D274)
Blocking Peptide
DR3 (CT) Blocking Peptide (Leinco Prod. No.: D274)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
References
1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-
2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.
3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
Related Products
DR3 (CT) Blocking Peptide (Leinco Prod. No.: D274)
DR3 (NT) Blocking Peptide (Leinco Prod. No.: D276)
Anti-Human DR3 (NT) (Leinco Prod. No.: D253)
Anti-Human DR3-Biotin (Antigen Aff. Puf. ) (Leinco Prod. No.: D344)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
