产品编号:D248
产品描述:Anti-Human TRAIL R4(Internal Domain)
反应种属:mouse, human, rat
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5370.00
订购:
说明书:
Rabbit Anti-Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4)
Purified No Carrier Protein
(TNFRSF10D, Decoy Receptor 2 (DCR2), CD264, TRUNDD, TR4)
Polyclonal Antibody
Prod. No.: D248
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4) recognizes Human TRAIL R4. This polyclonal antibody was purified using affinity chromatography.
Background:
TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
TRAIL R4 (Intracellular Domain) Blocking Peptide (Leinco Prod. No.: D266)
Blocking Peptide
TRAIL R4 (Intracellular Domain) Blocking Peptide (Leinco Prod. No.: D266)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Chan FK et al. (2005) Proc Natl Acad Sci USA 102: 18099
2. Sanlioglu S et al. (2005) BMC Cancer 5: 54
Related Products
TRAIL R4 (Intracellular Domain) Blocking Peptide (Leinco Prod. No.: D266)
Recombinant Human TRAIL R4 (Leinco Prod. No.: T403)
Anti-Human TRAIL R4 (Leinco Prod. No.: T452)
Anti-Human TRAIL R4 (Antigen Aff. Pur.) (Leinco Prod. No.: T472)
Anti-Human TRAIL R4-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T498)
Anti-Human TRAIL R4-R-phycoerythrin (R-PE) (Leinco Prod. No.: T513)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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