产品编号:A269
产品描述:Anti-Human Adiponectin(NT)
反应种属:mouse, human, rat
实验方法:IHC, WB
标记:
规格:0.1mg
供应商:leinco
价格(RMB):6195.00
订购:
说明书:
Rabbit Anti-Human Adiponectin
Purified No Carrier Protein
(ADIPOQ, ACDC, ACRP30, APM-1, APM1, GBP28)
Polyclonal Antibody
Prod. No.: A269
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Adiponectin recognizes an epitope near the N-terminus of Human, Mouse and Rat Adiponectin. This polyclonal antibody was purified using affinity chromatography.
Background:
Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimulated by insulin. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, Adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease. Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors. Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes. The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities.
Adiponectin (NT) Blocking Peptide (Leinco Prod. No.: A278) is applicable as a control peptide for blocking antibody binding in Western blotting.
Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
Purified Recombinant Human Adiponectin (>98%)
Blocking Peptide
Adiponectin (NT) Blocking Peptide (Leinco Prod. No.: A278)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
References
1. Fantuzzi, G. (2005) J. Allergy Clin. Immunol. 115:911
2. Rota, P. A. et al. (2003) Science 300:1394
3. Wong, G. W. et al. (2004) Proc. Natl. Acad. Sci. USA 101:10302
4. Li, W. et al. (2003) Nature 426:450
Related Products
Adiponectin (NT) Blocking Peptide (Leinco Prod. No.: A278)
Anti-Human Adiponectin (CT) (Leinco Prod. No.: A268)
Recombinant Human Adiponectin (Leinco Prod. No.: A321)
Anti-Mouse Adiponectin Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: A393)
Adiponectin (CT) Blocking Peptide (Leinco Prod. No.: A277)
Anti-Mouse Adiponectin (Antigen Aff. Pur.) (Leinco Prod. No.: A355)
Anti-human Adiponectin (Leinco Prod. No.: A369)
Recombinant Mouse Adiponectin (Leinco Prod. No.: A411)
Recombinant Human gAcrp30 (Leinco Prod. No.: A222)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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