产品编号:A272
产品描述:Anti-Human ATF6(NT)
反应种属:mouse, human
实验方法:
标记:
规格:0.1mg
供应商:leinco
价格(RMB):5700.00
订购:
说明书:
Rabbit Anti-Human Activating Transcription Factor 6 (ATF6)
Purified No Carrier Protein
Polyclonal Antibody
Prod. No.: A272
Host: Rabbit
Conc.: 0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage: 2-8°C
Description
Specificity:
Rabbit Anti-Human Activating Transcription Factor 6 (ATF6) recognizes an epitope near the N-terminus of Human and Mouse ATF6. This polyclonal antibody was purified using affinity chromatography.
Background:
Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR . ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78, but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus, and together with the transcription factor XBP-1, activates transcription of UPR-responsive genes.2-4 ATF6 has two isoforms (ATF6α and ATF6β); only ATF6α is recognized by this antibody.
Known Species Cross Reactivity: Ms+, Hu+
Immunogen
Activating Transcription Factor 6 (NT) Blocking Peptide (Leinco Prod. No.: A276)
Blocking Peptide
Activating Transcription Factor 6 (NT) Blocking Peptide (Leinco Prod. No.: A276)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
ELISA Cap, IHC (NBF/Par.), IHC (Frozen), WB
References
1. Liu, C. Y. et al. (2003) J. Cell Sci. 1861-2
2. Haze, K. et al. (1999) Mol. Cell. Biol. 10:3787
3. Little, E. et al. (1994) Crit. Rev. Eukaryot. Gene Expr. 4:1
4. Yoshida, H. et al. (2001) Cell 107:881
Related Products
Activating Transcription Factor 6 (NT) Blocking Peptide (Leinco Prod. No.: A276)
Anti-Human Activating Transcription Factor 6 (CT) (ATF6) (Leinco Prod. No.: A271)
Activating Transcription Factor 6 (CT) Blocking Peptide (Leinco Prod. No.: A275)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
