产品编号:M118
产品描述:Anti-Human Microtubules
反应种属:human
实验方法:IHC, IHC-F
标记:
规格:2.0 ml
供应商:leinco
价格(RMB):3300.00
订购:
说明书:
Anti-Human Microtublules
Tissue Culture Supernatant
Monoclonal Antibody
Prod. No.: M118
Clone: AE-8
Isotype: Mouse IgM
Pkg. Size: 2.0 ml
Description
Specificity:
Anti-Human Microtublules (Clone AE-8) recognizes an antigen associated with cytoplasmic human microtublules. The sequence of the epitope is unmapped.
Background:
Microtubules are one of the components of the cytoskeleton. They have a diameter of 25 nm and length varying from 200 nanometers to 25 micrometers. Microtubules serve as structural components within cells and are involved in many cellular processes including mitosis, cytokinesis, and vesicular transport. Microtubules are polymers of α- and β-tubulin dimers. The tubulin dimers polymerize end to end in protofilaments. The protofilaments then bundle in hollow cylindrical filaments. Typically, the protofilaments arrange themselves in an imperfect helix with one turn of the helix containing 13 tubulin dimers each from a different protofilament. The image above illustrates a small section of microtubule, a few αβ dimers in length. Another important feature of microtubule structure is polarity. Tubulin polymerizes end to end with the α subunit of one tubulin dimer contacting the β subunit of the next. Therefore, in a protofilament, one end will have the α subunit exposed while the other end will have the β subunit exposed. These ends are designated (−) and (+) respectively. The protofilaments bundle parallel to one another, so in a microtubule, there is one end, the (+) end, with only β subunits exposed while the other end, the (−) end, only has α subunits exposed.
Known Species Cross Reactivity: Hu+
Host Species
Mouse
Formulation
Anti-Human Microtublues is supplied in filtered tissue supernatant (RPMI-1640) pH-7.2 containig 0.09% sodium azide.
Storage and Stability
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
