产品编号:I-400
产品描述:Anti-Mouse Interferon α/β Receptor 1(IFNAR1/CD118)
反应种属:mouse
实验方法:IP
标记:
规格:200ug
供应商:leinco
价格(RMB):3735.00
订购:
说明书:
Anti-Mouse Interferon α/β Receptor 1 (IFNAR1)
Purified
(CD118, Ifar, Ifnar, Ifrc, INF-a receptor, Interferon-α/β receptor α chain precursor )
Monoclonal Antibody
Prod. No.: I-400
Clone: MAR1-5A3
Isotype: Mouse IgG1
Conc.: 0.2 mg/ml
Pkg. Size: Custom, 25 µg, 100 µg, 200 µg
Description
Specificity:
Mouse Anti-Mouse IFNAR1 (Clone MAR1-5A3) recognizes the extracellular domain of the IFNAR1 subunit of the mouse IFN-α/β receptor.
Antigen Distribution:
IFNAR1 and IFNAR2 are coexpressed on nearly all cells.
Background:
The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. IFNAR1 and IFNAR2 are coexpressed on nearly all cells and make up the heterodimeric receptor that binds all type I IFNs (IFN α and β). Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor and autoimmune responses In vivo.
Known Species Cross Reactivity: Ms+, Hu-
Host Species
Mouse
Immunogen
This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1.
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IP
References
1. Sheehan, K. C. F. et al. (2006) JICR 26(11):804
2. Dunn, G. P. et al. (2005) Nat. Immunol. 6(7):722
3. Fenner, J. E. et al. (2006) Nat. Immunol. 7(1):33
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
