产品编号:I-401

产品描述:Anti-Mouse Interferon α/β Receptor

反应种属:mouse

实验方法:FC, N, IP, WB

标记:

规格:500ug

供应商:leinco

价格(RMB):6225.00

订购:

说明书:

Anti-Mouse Interferon α/β Receptor (IFNAR1)
Purified Low Endotoxin Functional Formulation
(CD118, Ifar, Ifnar, Ifrc, INF-a receptor, Interferon-α/β receptor α chain precursor)
Monoclonal Antibody

Prod. No.: I-401
Clone:         MAR1-5A3
Isotype:     Mouse IgG1
Conc.:      ≥1.0 mg/ml
Pkg. Size:     1 mg, 50 µg, 200 µg, 500 µg

Description
Specificity:
Mouse Anti-Mouse IFNAR1 (Clone MAR1-5A3) recognizes the extracellular domain of the IFNAR1 subunit of the mouse IFN-α/β receptor.

Antigen Distribution:
IFNAR1 and IFNAR2 are coexpressed on nearly all cells.

Background:
The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. IFNAR1 and IFNAR2 are coexpressed on nearly all cells and make up the heterodimeric receptor that binds all type I IFNs (IFN α and β). Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor and autoimmune responses In vivo.

Known Species Cross Reactivity: Ms+, Hu-
Host Species
Mouse
Immunogen
This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1.
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purity
>98% by SDS Page and HPLC
Endotoxin
<0.5 EU/mg
Storage and Stability
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
FC, N, IP, WB

References
1. Sheehan, K. C. F. et al. (2006) JICR 26(11):804
2. Dunn, G. P. et al. (2005) Nat. Immunol. 6(7):722
3. Fenner, J. E. et al. (2006) Nat. Immunol. 7(1):33
4. Biron, C. A. et al. (2007) J Exp Med. 204(10): 2383
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.