产品编号:I-436

产品描述:Anti-Mouse IL-1β Purified

反应种属:mouse

实验方法:ELISA, IHC, IP, WB

标记:

规格:1.0mg

供应商:leinco

价格(RMB):6000.00

订购:

说明书:

Anti-Mouse Interleukin-1 Beta (IL-1β)
Purified Low Endotoxin Functional Formulation
(IL1B, IL-1, IL1-Beta, IL1F2)
Monoclonal Antibody

Prod. No.: I-437
Clone:        B122
Isotype:     Armenian Hamster IgG
Conc.:      1.0 mg/ml
Pkg. Size:    Custom, 50 µg, 500 µg, 1.0 mg

Description
Specificity:
Armenian Hamster Anti-Mouse IL-1β (Clone B122) recognizes Mouse IL-1β. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3

Host Species
Armenian Hamster
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Stability
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
ELISA Cap, IHC (NBF/Par.), N, IP, WB

References
1. Dinarello CA et al. (1996) Blood 87: 2095
2. Yuan et al. (1993) Cell 75: 641
3. Shin Maeda et al. (2005) Science 4: 735

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.