产品编号:M1088

产品描述:Anti-Human MMP-13

反应种属:human

实验方法:WB

标记:

规格:0.2 mg

供应商:leinco

价格(RMB):3780.00

订购:

说明书:

Anti-Human Matrix Metalloproteinase-13(MMP-13)
Purified No Carrier Protein
(Collagenase 3, CLG3, CL3)
Monoclonal Antibody
Prod. No.:  M1088
Clone:      M31.387
Isotype:    Mouse IgG1
Conc.:      0.1 mg/ml
Pkg. Size:  0.2 mg
Storage:    2-8°C

Description
Specificity:
Anti-Human MMP-13 (clone M31.387) was produced in mice using a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13. This antibody recognizes the approximately 54-60 kDa latent human MMP-13.

Background:
Matrix metallopeptidase 13 (collagenase 3), also known as MMP13, is a glycosylated protein1 and a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, which is expressed in the skeleton during embryonic development2 and are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-13 is tightly bound to tissues and utilizes heparan sulfate proteoglycans as extracellular docking molecules. It is produced by many different cell types as an inactive proform that requires proteolytic activation to gain activity.3 Mutations causing lack of MMP-13 expression have been shown to be associated with skeletal disorders characterized by defective growth and modeling of the spine and long bones (spondyloepimetaphyseal dysplasias).4

Known Species Cross Reactivity: Hu+
Host Species
Mouse
Immunogen
a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13
Formulation
This purified antibody is formulated with no carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
Storage and Stability
The antibody should be stored at -20°C. Avoid repeated freezing and thawing. This product does not contain preservatives.
Reported Applications
WB

References
1. Knäuper V et al. (1996) J Biol. Chem. 271: 17124
2. Stephen M. Krane et al. (2004) National Acad. Scien.
3. Woessner JF. et al. (2000) J Biol. Chem. 275: 4183
4. Kennedy AM. et al. (2005) J Clin. Invest. 115: 2832

Related Products
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Anti-Human MMP-13 (Antigen Aff. Pur.) (Leinco Prod. No.: M1275)
Anti-Human MMP-13-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: M1309)

Products are for research use only. Not for use in diagnostic or therapeutic procedures