| Prod. No.: |
P110 |
| Clone: |
MC5 |
| Isotype: |
Mouse IgG2a |
| Pkg. Size: |
1.0 ml |
| Storage: |
2 - 8°C |
Description
Specificity:
Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.1 Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.1,2 Monoclonal MC5 reacts with PKC-α/ß1/ß2 isoforms.
Background:
Anti-Protein Kinase C (PKC) has been covalently conjugated to 4% cross-linked agarose using conjugation chemistries to reduce non-specific binding and optimize binding of Protein Kinase C. Anti-Protein Kinase C-Agarose may be used to isolate Protein Kinase C.
Bead Size
75-300 µm (50-200 mesh)
Known Species Cross Reactivity: Ms+, Hu+, Rt+, Rb+, Bov+
Host Species
Mouse
Formulation
Anti-Protein Kinase C-Agarose is supplied in 0.01 M phosphate buffered saline (PBS) pH 7.2, 0.09% sodium azide as a preservative.
Storage and Stability
Stable when stored at 2 - 8°C.
Related Products
Products are for research use only. Not for use in diagnostic or therapeutic procedures
