产品编号:HIV-156-2ug

产品描述:Recombinant HIV-1 nef , Clade B

反应种属:

实验方法:

标记:

规格:2µg

供应商:Prospec

价格(RMB):800.00

订购:

说明书:

HIV-1 nef, Clade B
HIV-1 nef Clade B Recombinant
Catalog No. HIV-156

Introduction:
HIV-1 Nef is a 27kDa protein highly produced after a very short time after virus infection. HIV-1 Nef is an essential factor for efficient viral replication and phatogenesis.
HIV-1 Nef facilitates virus replication and improves virions infectivity. HIV-1 Nef exerts pleiotropic effect. HIV-1 Nef down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrindependent endocytosis of this antigen to target it to lysosomial degradation. HIV-1 Nef guards the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. HIV-1 Nef protein bypasses host Tcell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation.

Description:
The E.coli derived 27 kDa recombinant HIV-1 Nef Clade-B protein is a single non-glycosylated polypeptide chain.

Source:
Escherichia Coli.

Physical Appearance:
Sterile filtered lyophilized protein.

Purity:
Greater than 90.0% as determined by HPLC analysis and SDS-PAGE.

Solubility:
Reconstitute with PBS in apirogenic water or buffer with a minimum ionic force to guarantee the correct folding of Nef protein.

Stability:
Protein is shipped at ambient temperature.
Upon arrival, Store at -20°C.

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.