产品编号:ENZ-400-10ug
产品描述:Recombinant Human COMT(COMT)
反应种属:
实验方法:
标记:
规格:10µg
供应商:Prospec
价格(RMB):1820.00
订购:
说明书:
COMT Human
Catechol-O-Methyltransferase Human Recombinant
Catalog No. ENZ-400
Synonyms:
COMT, EC 2.1.1.6, Catechol O-methyltransferase.
Introduction:
COMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to catechol substrates such as the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the main degradative pathways of the catecholamine transmitters. COMT COMT is located in the postsynaptic neuron and is involved in the metabolism of catechol estrogen drugs used in the treatment of hypertension, asthma, Parkinson disease and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT appears in tissues in 2 forms, a soluble form and a membrane-bound form which differ in their N-termini. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease.
Description:
COMT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (51-271 a.a.) & having a molecular mass of 24.4 kDa.
The COMT is purified by proprietary chromatographic techniques.
Source:
Escherichia Coli.
Physical Appearance:
Sterile Filtered clear solution.
Formulation:
COMT protein in 20mM Tris-buffer, pH-8, 1mM MgCl2 and 10% Glycerol.
Purity:
Greater than 95.0% as determined by SDS-PAGE.
Stability:
Store vial at -20°C to -80°C.
When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
Amino Acid Sequence:
MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
