产品编号:L96498226-200

产品描述:Anti Human Fibrinogen. Affinity purified on human fibrogen agarose. Labelled with biotin

反应种属:

实验方法:

标记:

规格:200ul

供应商:Biosense

价格(RMB):6750.00

订购:

说明书:

Anti Human Fibrinogen

Background
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient
s blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al).

Immunogen: Purified full length native protein

Alternative antigen names: FGA; FGB; FGG; Fibrinogen alpha chain; Fibrinogen beta chain;